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Target
Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50435962
Substrate
n/a
Meas. Tech.
ChEMBL_964080 (CHEMBL2394433)
IC50
31±n/a nM
Citation
 Yang, D; Arifhodzic, L; Ganellin, CR; Jenkinson, DH Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels. Eur J Med Chem 63:907-23 (2013) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
K3 | KCNN3 | KCNN3_HUMAN | Small conductance calcium-activated potassium channel protein 3 | Small conductance calcium-activated potassium channel protein 3 (KCa2.3)
Type:
Protein
Mol. Mass.:
82053.75
Organism:
Homo sapiens (Human)
Description:
Q9UGI6
Residue:
731
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
  
Inhibitor
Name:
BDBM50435962
Synonyms:
CHEMBL2391655
Type:
Small organic molecule
Emp. Form.:
C31H34N4
Mol. Mass.:
462.6263
SMILES:
C1CCn2[cH+]cc([NH2+]Cc3cccc(C[NH2+]c4c[cH+]n(CC1)c1ccccc41)c3)c1ccccc21
Structure:
Search PDB for entries with ligand similarity: