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Target
Transforming protein RhoA
Ligand
BDBM50436241
Substrate
n/a
Meas. Tech.
ChEMBL_966397 (CHEMBL2398834)
IC50
7400±n/a nM
Citation
 Bell, JL; Haak, AJ; Wade, SM; Kirchhoff, PD; Neubig, RR; Larsen, SD Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett 23:3826-32 (2013) [PubMed]  Article 
Target
Name:
Transforming protein RhoA
Synonyms:
ARH12 | ARHA | RHO12 | RHOA | RHOA_HUMAN | Rho cDNA clone 12 | h12
Type:
PROTEIN
Mol. Mass.:
21766.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_966397
Residue:
193
Sequence:
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLVL
  
Inhibitor
Name:
BDBM50436241
Synonyms:
CHEMBL2398672
Type:
Small organic molecule
Emp. Form.:
C27H23F6N3O3
Mol. Mass.:
551.4802
SMILES:
FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1cccc(OCc2ccccn2)c1
Structure:
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