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Target
Transforming protein RhoA
Ligand
BDBM50436246
Substrate
n/a
Meas. Tech.
ChEMBL_966397 (CHEMBL2398834)
IC50
66000±n/a nM
Citation
 Bell, JL; Haak, AJ; Wade, SM; Kirchhoff, PD; Neubig, RR; Larsen, SD Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett 23:3826-32 (2013) [PubMed]  Article 
Target
Name:
Transforming protein RhoA
Synonyms:
ARH12 | ARHA | RHO12 | RHOA | RHOA_HUMAN | Rho cDNA clone 12 | h12
Type:
PROTEIN
Mol. Mass.:
21766.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_966397
Residue:
193
Sequence:
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLVL
  
Inhibitor
Name:
BDBM50436246
Synonyms:
CHEMBL2398710
Type:
Small organic molecule
Emp. Form.:
C21H17F6N3O4
Mol. Mass.:
489.3678
SMILES:
[O-][N+](=O)c1cccc(NC(=O)C2CCCN(C2)C(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1
Structure:
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