Target
Apoptosis regulator Bcl-2
Ligand
BDBM50436645
Substrate
n/a
Meas. Tech.
ChEMBL_967614 (CHEMBL2399234)
IC50
>10000±n/a nM
Citation
 Sleebs, BEKersten, WJKulasegaram, SNikolakopoulos, GHatzis, EMoss, RMParisot, JPYang, HCzabotar, PEFairlie, WDLee, EFAdams, JMChen, Lvan Delft, MFLowes, KNWei, AHuang, DCColman, PMStreet, IPBaell, JBWatson, KLessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem 56:5514-40 (2014) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50436645
Synonyms:
CHEMBL2398262
Type:
Small organic molecule
Emp. Form.:
C22H17N5O2S
Mol. Mass.:
415.468
SMILES:
OC(=O)c1ccnc(n1)-c1ccc2CCCC(=NNc3nc4ccccc4s3)c2c1 |w:17.18|
Structure:
Search PDB for entries with ligand similarity: