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Target
Bcl-2-like protein 1
Ligand
BDBM50436643
Substrate
n/a
Meas. Tech.
ChEMBL_967619 (CHEMBL2399239)
IC50
2200±n/a nM
Citation
 Sleebs, BE; Kersten, WJ; Kulasegaram, S; Nikolakopoulos, G; Hatzis, E; Moss, RM; Parisot, JP; Yang, H; Czabotar, PE; Fairlie, WD; Lee, EF; Adams, JM; Chen, L; van Delft, MF; Lowes, KN; Wei, A; Huang, DC; Colman, PM; Street, IP; Baell, JB; Watson, K; Lessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem 56:5514-40 (2014) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50436643
Synonyms:
3-(5-(1-(2-(Benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)-benzoic acid (Compound 1b) | CHEMBL2398292
Type:
Small organic molecule
Emp. Form.:
C20H15N3O3S
Mol. Mass.:
377.416
SMILES:
CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cccc(c1)C(O)=O |w:3.3|
Structure:
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