Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50292604
Substrate
n/a
Meas. Tech.
ChEMBL_969180 (CHEMBL2404437)
Ki
1400±n/a nM
Citation
 Darvesh, S; Macdonald, IR; Martin, E Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems. Bioorg Med Chem Lett 23:3822-5 (2013) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50292604
Synonyms:
3-(diethylamino)propyl 10H-phenothiazine-10-carboxylate | CHEMBL519609
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2S
Mol. Mass.:
356.482
SMILES:
CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc12
Structure:
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