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TargetX-linked inhibitor of apoptosis protein (XIAP)
LigandBDBM44311
Substrate/Competitorn/a
Meas. Tech.ChEMBL_971509
Ki 1830±n/a nM
Citation Ardecky, RJWelsh, KFinlay, DLee, PSGonzález-López, MGanji, SRRavanan, PMace, PDRiedl, SJVuori, KReed, JCCosford, ND Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Bioorg Med Chem Lett23:4253-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
X-linked inhibitor of apoptosis protein (XIAP)
Name:X-linked inhibitor of apoptosis protein (XIAP)
Synonyms:E3 ubiquitin-protein ligase XIAP | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis
Type:Protein
Mol. Mass.:56685.27
Organism:Homo sapiens (Human)
Description:P98170
Residue:497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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BDBM44311
NameBDBM44311
Synonyms:(2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]-3-methyl-N-[(2S)-1-oxo-1-(phenylhydrazo)propan-2-yl]butanamide;formic acid | (2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methyl-N-[(2S)-1-oxo-1-(2-phenylhydrazinyl)propan-2-yl]butanamide;formic acid | (2S)-2-[[(2S)-2-aminopropanoyl]amino]-N-[(1S)-2-keto-1-methyl-2-(N'-phenylhydrazino)ethyl]-3-methyl-butyramide;formic acid | (2S)-2-[[(2S)-2-azanylpropanoyl]amino]-3-methyl-N-[(2S)-1-oxidanylidene-1-(2-phenylhydrazinyl)propan-2-yl]butanamide;methanoic acid | CHEMBL1617819 | MLS-0412113.0001 | cid_44182205
TypeSmall organic molecule
Emp. Form.C17H27N5O3
Mol. Mass.349.428
SMILESCC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)NNc1ccccc1
Structure
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