Target
Aurora kinase B
Ligand
BDBM50437161
Substrate
n/a
Meas. Tech.
ChEMBL_970204 (CHEMBL2406471)
IC50
11±n/a nM
Citation
 Steinig, AGLi, AHWang, JChen, XDong, HFerraro, CJin, MKadalbajoo, MKleinberg, AStolz, KMTavares-Greco, PAWang, TAlbertella, MRPeng, YCrew, LKahler, JKan, JSchulz, RCooke, ABittner, MTurton, RWFranklin, MGokhale, PLandfair, DMantis, CWorkman, JWild, RPachter, JEpstein, DMulvihill, MJ Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases. Bioorg Med Chem Lett 23:4381-7 (2013) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50437161
Synonyms:
CHEMBL2401832
Type:
Small organic molecule
Emp. Form.:
C21H19Cl2FN4O3
Mol. Mass.:
465.305
SMILES:
C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl |r,t:15|
Structure:
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