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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50437199
Substrate
n/a
Meas. Tech.
ChEMBL_969415 (CHEMBL2405605)
IC50
13502±n/a nM
Citation
 Lin, H; Hu, GX; Guo, J; Ge, Y; Liang, G; Lian, QQ; Chu, Y; Yuan, X; Huang, P; Ge, RS Mono-carbonyl curcumin analogues as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. Bioorg Med Chem Lett 23:4362-6 (2013) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
31889.48
Organism:
Rattus norvegicus (rat)
Description:
P16232
Residue:
288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
  
Inhibitor
Name:
BDBM50437199
Synonyms:
2,6-Bis(4-Fluorobenzylidene)Cyclohexanone | CHEMBL477256
Type:
Small organic molecule
Emp. Form.:
C20H16F2O
Mol. Mass.:
310.3372
SMILES:
Fc1ccc(\C=C2/CCC\C(=C/c3ccc(F)cc3)C2=O)cc1
Structure:
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