Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50437703
Substrate
n/a
Meas. Tech.
ChEMBL_974632 (CHEMBL2410558)
IC50
200±n/a nM
Citation
 Moore, JD; Potter, A Pin1 inhibitors: Pitfalls, progress and cellular pharmacology. Bioorg Med Chem Lett 23:4283-91 (2013) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
  
Inhibitor
Name:
BDBM50437703
Synonyms:
CHEMBL2409070
Type:
Small organic molecule
Emp. Form.:
C22H14FN3O9
Mol. Mass.:
483.3597
SMILES:
Oc1c(cc(cc1[N+]([O-])=O)-c1c(O)c(cc(F)c1[N+]([O-])=O)[N+]([O-])=O)C(=O)C1CCc2ccccc12
Structure:
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