Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50437744
Substrate
n/a
Meas. Tech.
ChEMBL_973380 (CHEMBL2410086)
IC50
>10000±n/a nM
Citation
 Kwak, HJ; Pyun, YM; Kim, JY; Pagire, HS; Kim, KY; Kim, KR; Rhee, SD; Jung, WH; Song, JS; Bae, MA; Lee, DH; Ahn, JH Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorg Med Chem Lett 23:4713-8 (2013) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50437744
Synonyms:
CHEMBL2409566
Type:
Small organic molecule
Emp. Form.:
C32H30N4O4
Mol. Mass.:
534.605
SMILES:
Cc1oc(nc1C(=O)Nc1ccc2nc([nH]c2c1)-c1ccc(cc1)C1CCC(CC(O)=O)CC1)-c1ccccc1 |(2.06,-32.51,;.92,-33.54,;-.59,-33.23,;-1.37,-34.57,;-.32,-35.71,;1.08,-35.07,;2.42,-35.83,;2.43,-37.37,;3.75,-35.06,;5.09,-35.82,;5.09,-37.36,;6.42,-38.13,;7.76,-37.34,;9.23,-37.81,;10.12,-36.55,;9.21,-35.32,;7.74,-35.8,;6.41,-35.05,;11.66,-36.53,;12.44,-37.86,;13.98,-37.84,;14.73,-36.5,;13.94,-35.17,;12.41,-35.19,;16.27,-36.47,;17.05,-37.8,;18.59,-37.79,;19.35,-36.45,;20.89,-36.43,;21.65,-35.09,;23.19,-35.08,;20.87,-33.77,;18.56,-35.12,;17.02,-35.13,;-2.89,-34.74,;-3.8,-33.49,;-5.33,-33.66,;-5.94,-35.08,;-5.03,-36.32,;-3.51,-36.14,)|
Structure:
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