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Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Ligand
BDBM50437806
Substrate
n/a
Meas. Tech.
ChEMBL_973766 (CHEMBL2412049)
IC50
1600±n/a nM
Citation
 Jansson, AM; Wieckowska, A; Björkelid, C; Yahiaoui, S; Sooriyaarachchi, S; Lindh, M; Bergfors, T; Dharavath, S; Desroses, M; Suresh, S; Andaloussi, M; Nikhil, R; Sreevalli, S; Srinivasa, BR; Larhed, M; Jones, TA; Karlén, A; Mowbray, SL DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. J Med Chem 56:6190-9 (2013) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:
DXR_MYCTU | dxr
Type:
PROTEIN
Mol. Mass.:
42846.92
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_1474510
Residue:
413
Sequence:
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
  
Inhibitor
Name:
BDBM50437806
Synonyms:
CHEMBL2407346
Type:
Small organic molecule
Emp. Form.:
C9H13N2O5P
Mol. Mass.:
260.1837
SMILES:
ON(CCCP(O)(O)=O)C(=O)c1cccnc1
Structure:
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