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Target
Chymotrypsinogen B
Ligand
BDBM50437995
Substrate
n/a
Meas. Tech.
ChEMBL_972955 (CHEMBL2412036)
IC50
170±n/a nM
Citation
 Crocetti, L; Schepetkin, IA; Cilibrizzi, A; Graziano, A; Vergelli, C; Giomi, D; Khlebnikov, AI; Quinn, MT; Giovannoni, MP Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. J Med Chem 56:6259-72 (2013) [PubMed]  Article 
Target
Name:
Chymotrypsinogen B
Synonyms:
A0A2R8YG87_HUMAN | Beta-chymotrypsin | CTRB1 | Chymotrypsin B chain A | Chymotrypsin B chain B | Chymotrypsin B chain C | Chymotrypsinogen B
Type:
PROTEIN
Mol. Mass.:
27871.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_216634
Residue:
263
Sequence:
MAFLWLLSCWALLGTTFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKILAAN
  
Inhibitor
Name:
BDBM50437995
Synonyms:
CHEMBL2409570
Type:
Small organic molecule
Emp. Form.:
C20H19N3O4
Mol. Mass.:
365.3826
SMILES:
CCOC(=O)c1nn(C(=O)c2cccc(C)c2)c2ccc(NC(C)=O)cc12
Structure:
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