Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM51911
Substrate
n/a
Meas. Tech.
ChEMBL_973068 (CHEMBL2412649)
IC50
660±n/a nM
Citation
 Tan, X; Furio, L; Reboud-Ravaux, M; Villoutreix, BO; Hovnanian, A; El Amri, C 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett 23:4547-51 (2013) [PubMed]  Article 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM51911
Synonyms:
(4-isopropoxybenzyl)-[3-(2-methoxyphenyl)-3-(4-methoxyphenyl)propyl]amine | 3-(2-methoxyphenyl)-3-(4-methoxyphenyl)-N-[(4-propan-2-yloxyphenyl)methyl]-1-propanamine | 3-(2-methoxyphenyl)-3-(4-methoxyphenyl)-N-[(4-propan-2-yloxyphenyl)methyl]propan-1-amine | MLS001164329 | SMR000539687 | cid_3730081
Type:
Small organic molecule
Emp. Form.:
C27H33NO3
Mol. Mass.:
419.5558
SMILES:
COc1ccc(cc1)C(CCNCc1ccc(OC(C)C)cc1)c1ccccc1OC
Structure:
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