Reaction Details Report a problem with these data
Target
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Ligand
BDBM50144454
Substrate
n/a
Meas. Tech.
ChEMBL_973242 (CHEMBL2410458)
IC50
40738±n/a nM
Citation
Soares, FA; Sesti-Costa, R; da Silva, JS; de Souza, MC; Ferreira, VF; Santos, Fda C; Monteiro, PA; Leitão, A; Montanari, CA Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity. Bioorg Med Chem Lett 23:4597-601 (2013) [PubMed] Article
More Info.:
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Synonyms:
G3PG_TRYCR
Type:
PROTEIN
Mol. Mass.:
39070.68
Organism:
Trypanosoma cruzi
Description:
ChEMBL_973242
Residue:
359
Sequence:
MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAAEGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHVVSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQKTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL
Inhibitor
Name:
BDBM50144454
Synonyms:
1-(3,4-Bis-benzoyloxy-5-benzoyloxymethyl-tetrahydro-furan-2-yl)-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | BDBM50438275 | CHEMBL2408380
Type:
Small organic molecule
Emp. Form.:
C38H30ClNO10
Mol. Mass.:
696.099
SMILES:
CCOC(=O)c1cn([C@@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)c2ccc(Cl)cc2c1=O |r|