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Target
Heme oxygenase 2
Ligand
BDBM50271548
Substrate
n/a
Meas. Tech.
ChEMBL_976174 (CHEMBL2415823)
IC50
24000±n/a nM
Citation
 Salerno, L; Pittalà, V; Romeo, G; Modica, MN; Siracusa, MA; Di Giacomo, C; Acquaviva, R; Barbagallo, I; Tibullo, D; Sorrenti, V Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. Bioorg Med Chem 21:5145-53 (2013) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM50271548
Synonyms:
1-(4-(2-bromophenoxy)butyl)-1H-imidazole | CHEMBL504297
Type:
Small organic molecule
Emp. Form.:
C13H15BrN2O
Mol. Mass.:
295.175
SMILES:
Brc1ccccc1OCCCCn1ccnc1
Structure:
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