Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSUMO-activating enzyme
LigandBDBM50278299
Substrate/Competitorn/a
Meas. Tech.ChEMBL_977623
IC50 13400±n/a nM
Citation Kumar, AIto, AHirohama, MYoshida, MZhang, KY Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors. Bioorg Med Chem Lett23:5145-9 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
SUMO-activating enzyme
Name:SUMO-activating enzyme
Synonyms:SUMO E1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 977623
Components:This complex has 2 components.
Component 1
Name:SUMO-activating enzyme subunit 2 (SAE2)
Synonyms:6.3.2.- | Anthracycline-associated resistance ARX | SAE2 | SUMO-activating enzyme subunit 2 | UBA2 | UBLE1B | Ubiquitin-like 1-activating enzyme E1B | Ubiquitin-like modifier-activating enzyme 2
Type:Enzyme
Mol. Mass.:71206.17
Organism:Homo sapiens (Human)
Description:Q9UBT2
Residue:640
Sequence:
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ
FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA
ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS
EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST
KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ
NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN
LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK
QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV
QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK
DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN
ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:SUMO1 activating enzyme subunit 1
Synonyms:SUMO-activating enzyme subunit 1 (SAE1)
Type:Enzyme Catalytic Domain
Mol. Mass.:38440.84
Organism:Homo sapiens
Description:gi_17390638
Residue:346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50278299
NameBDBM50278299
Synonyms:1-(6-(7-chloroquinazolin-4-yloxy)pyridin-3-yl)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)urea | CHEMBL471230
TypeSmall organic molecule
Emp. Form.C26H24ClN5O4
Mol. Mass.505.953
SMILESCOc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(Cl)ccc34)nc2)cc1OC1CCCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a