Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50439473
Substrate
n/a
Meas. Tech.
ChEMBL_979046 (CHEMBL2421099)
IC50
13±n/a nM
Citation
 Bolton, SA; Sutton, JC; Anumula, R; Bisacchi, GS; Jacobson, B; Slusarchyk, WA; Treuner, UD; Wu, SC; Zhao, G; Pi, Z; Sheriff, S; Smirk, RA; Bisaha, S; Cheney, DL; Wei, A; Schumacher, WA; Hartl, KS; Liu, E; Zahler, R; Seiler, SM Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold. Bioorg Med Chem Lett 23:5239-43 (2013) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50439473
Synonyms:
CHEMBL2417907
Type:
Small organic molecule
Emp. Form.:
C29H29N5O5
Mol. Mass.:
527.5711
SMILES:
COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Structure:
Search PDB for entries with ligand similarity: