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Target
Sodium- and chloride-dependent glycine transporter 2
Ligand
BDBM50335001
Substrate
n/a
Meas. Tech.
ChEMBL_980598 (CHEMBL2423115)
IC50
340±n/a nM
Citation
 Sugane, T; Tobe, T; Hamaguchi, W; Shimada, I; Maeno, K; Miyata, J; Suzuki, T; Kimizuka, T; Sakamoto, S; Tsukamoto, S Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors. J Med Chem 56:5744-56 (2014) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 2
Synonyms:
Glycine transporter 2 | Glyt2 | SC6A5_RAT | Slc6a5
Type:
PROTEIN
Mol. Mass.:
87845.43
Organism:
Rattus norvegicus
Description:
ChEMBL_980598
Residue:
799
Sequence:
MDCSAPKEMNKPPTNILEATVPGHRDSPRAPRTSPEQDLPAAAPAAAVQPPRVPRSASTGAQTFQSADARACEAQRPGVGFCKLSSPQAQATSAALRDLSEGHSAQANPPSGAAGAGNALHCKIPALRGPEEDENVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
  
Inhibitor
Name:
BDBM50335001
Synonyms:
3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole | CHEMBL1649588
Type:
Small organic molecule
Emp. Form.:
C21H16FN3
Mol. Mass.:
329.3702
SMILES:
Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(14.8,-4.75,;13.34,-4.27,;12.87,-2.81,;11.33,-2.81,;10.85,-4.27,;9.53,-5.05,;9.53,-6.59,;8.2,-7.36,;6.86,-6.59,;6.86,-5.06,;8.18,-4.28,;5.54,-7.37,;4.2,-6.6,;2.88,-7.37,;2.87,-8.92,;4.21,-9.69,;5.54,-8.92,;12.09,-5.18,;12.09,-6.71,;10.76,-7.47,;10.75,-9.01,;12.09,-9.79,;13.43,-9.01,;13.42,-7.47,;14.75,-6.7,)|
Structure:
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