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Target
Protein Wnt-3a
Ligand
BDBM50439801
Substrate
n/a
Meas. Tech.
ChEMBL_977441 (CHEMBL2422476)
IC50
1100±n/a nM
Citation
 Shultz, MD; Cheung, AK; Kirby, CA; Firestone, B; Fan, J; Chen, CH; Chen, Z; Chin, DN; Dipietro, L; Fazal, A; Feng, Y; Fortin, PD; Gould, T; Lagu, B; Lei, H; Lenoir, F; Majumdar, D; Ochala, E; Palermo, MG; Pham, L; Pu, M; Smith, T; Stams, T; Tomlinson, RC; Touré, BB; Visser, M; Wang, RM; Waters, NJ; Shao, W Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem 56:6495-511 (2013) [PubMed]  Article 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM50439801
Synonyms:
CHEMBL2419696
Type:
Small organic molecule
Emp. Form.:
C23H23ClFN3O3
Mol. Mass.:
443.898
SMILES:
COc1cc(Cl)c(cc1C(=O)NCCN1CCC(CC1)C(=O)c1ccc(F)cc1)C#N
Structure:
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