Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM50439821
Substrate
n/a
Meas. Tech.
ChEMBL_977441 (CHEMBL2422476)
IC50
4630±n/a nM
Citation
 Shultz, MD; Cheung, AK; Kirby, CA; Firestone, B; Fan, J; Chen, CH; Chen, Z; Chin, DN; Dipietro, L; Fazal, A; Feng, Y; Fortin, PD; Gould, T; Lagu, B; Lei, H; Lenoir, F; Majumdar, D; Ochala, E; Palermo, MG; Pham, L; Pu, M; Smith, T; Stams, T; Tomlinson, RC; Touré, BB; Visser, M; Wang, RM; Waters, NJ; Shao, W Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem 56:6495-511 (2013) [PubMed]  Article 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM50439821
Synonyms:
CHEMBL2419896
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2
Mol. Mass.:
242.2732
SMILES:
Cc1ccc(cc1)-c1nc2CCOCc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: