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Target
Serine/threonine-protein kinase DCLK3
Ligand
BDBM50440018
Substrate
n/a
Meas. Tech.
ChEMBL_982253 (CHEMBL2429320)
Kd
1800±n/a nM
Citation
 Palmer, WS; Alam, M; Arzeno, HB; Chang, KC; Dunn, JP; Goldstein, DM; Gong, L; Goyal, B; Hermann, JC; Hogg, JH; Hsieh, G; Jahangir, A; Janson, C; Jin, S; Ursula Kammlott, R; Kuglstatter, A; Lukacs, C; Michoud, C; Niu, L; Reuter, DC; Shao, A; Silva, T; Trejo-Martin, TA; Stein, K; Tan, YC; Tivitmahaisoon, P; Tran, P; Wagner, P; Weller, P; Wu, SY Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead. Bioorg Med Chem Lett 23:1486-92 (2013) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase DCLK3
Synonyms:
DCAMKL3 | DCDC3C | DCLK3 | DCLK3_HUMAN | KIAA1765 | Serine/threonine-protein kinase DCLK3
Type:
PROTEIN
Mol. Mass.:
73837.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586565
Residue:
648
Sequence:
MGKEPLTLKSIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALKGDHRCGETETPKSCSEVAGCKAAMRHQGKIPEELSLDDRARTQKKWGRGKWEPEPSSKPPREATLEERHARGEKHLGVEIEKTSGEIIRCEKCKRERELQQSLERERLSLGTSELDMGKGPMYDVEKLVRTRSCRRSPEANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMDKKEDRGPEDQESHAQGAAKAKKDLVEVLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKLRRTRGEEKEAEKEKKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQVS
  
Inhibitor
Name:
BDBM50440018
Synonyms:
CHEMBL2425628
Type:
Small organic molecule
Emp. Form.:
C28H37N5O5S
Mol. Mass.:
555.689
SMILES:
CS(=O)(=O)CCCOc1cccc2n(ccc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)C(=O)N2CCC(O)CC2)n1 |r,wU:23.24,wD:26.31,(28.71,-17.43,;28.01,-18.78,;27.59,-20.26,;29.41,-19.4,;26.53,-18.36,;26.13,-16.88,;24.65,-16.47,;24.27,-14.99,;22.78,-14.58,;21.71,-15.67,;20.2,-15.25,;19.81,-13.8,;20.9,-12.71,;20.81,-11.17,;22.23,-10.62,;23.2,-11.81,;22.38,-13.1,;19.48,-10.41,;19.47,-8.86,;18.15,-8.1,;16.81,-8.87,;16.81,-10.41,;15.47,-11.19,;14.13,-10.42,;12.8,-11.2,;11.46,-10.44,;11.44,-8.89,;12.79,-8.11,;14.12,-8.88,;10.09,-8.13,;10.08,-6.58,;8.76,-8.89,;7.43,-8.12,;6.1,-8.9,;6.1,-10.44,;4.77,-11.21,;7.43,-11.21,;8.76,-10.44,;18.15,-11.18,)|
Structure:
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