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Target
Deoxycytidine kinase
Ligand
BDBM50440151
Substrate
n/a
Meas. Tech.
ChEMBL_981695 (CHEMBL2429677)
IC50
3.0±n/a nM
Citation
 Murphy, JM; Armijo, AL; Nomme, J; Lee, CH; Smith, QA; Li, Z; Campbell, DO; Liao, HI; Nathanson, DA; Austin, WR; Lee, JT; Darvish, R; Wei, L; Wang, J; Su, Y; Damoiseaux, R; Sadeghi, S; Phelps, ME; Herschman, HR; Czernin, J; Alexandrova, AN; Jung, ME; Lavie, A; Radu, CG Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem 56:6696-708 (2013) [PubMed]  Article 
Target
Name:
Deoxycytidine kinase
Synonyms:
DCK_MOUSE | Dck
Type:
PROTEIN
Mol. Mass.:
30361.42
Organism:
Mus musculus
Description:
ChEMBL_981695
Residue:
260
Sequence:
MATPPKRFCPSPSTSSEGTRIKKISIEGNIAAGKSTFVNILKQASEDWEVVPEPVARWCNVQSTQEEFEELTTSQKSGGNVLQMMYEKPERWSFTFQSYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFGQSLELDGIIYLRATPEKCLNRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTSFDYLQEVPVLTLDVNEDFKDKHESLVEKVKEFLSTL
  
Inhibitor
Name:
BDBM50440151
Synonyms:
CHEMBL2426558
Type:
Small organic molecule
Emp. Form.:
C20H24FN5O2S2
Mol. Mass.:
449.565
SMILES:
CCCc1sc(nc1CSc1nc(N)cc(N)n1)-c1ccc(OC)c(OCCF)c1
Structure:
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