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Target
Deoxycytidine kinase
Ligand
BDBM50440172
Substrate
n/a
Meas. Tech.
ChEMBL_981694 (CHEMBL2429676)
IC50
4.9±n/a nM
Citation
 Murphy, JM; Armijo, AL; Nomme, J; Lee, CH; Smith, QA; Li, Z; Campbell, DO; Liao, HI; Nathanson, DA; Austin, WR; Lee, JT; Darvish, R; Wei, L; Wang, J; Su, Y; Damoiseaux, R; Sadeghi, S; Phelps, ME; Herschman, HR; Czernin, J; Alexandrova, AN; Jung, ME; Lavie, A; Radu, CG Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem 56:6696-708 (2013) [PubMed]  Article 
Target
Name:
Deoxycytidine kinase
Synonyms:
DCK | DCK_HUMAN
Type:
PROTEIN
Mol. Mass.:
30510.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1437135
Residue:
260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
  
Inhibitor
Name:
BDBM50440172
Synonyms:
CHEMBL2426574
Type:
Small organic molecule
Emp. Form.:
C21H28N6O4S3
Mol. Mass.:
524.68
SMILES:
CCCc1sc(nc1CSc1nc(N)cc(N)n1)-c1ccc(OC)c(OCCNS(C)(=O)=O)c1
Structure:
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