Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDeoxycytidine kinase
LigandBDBM50440157
Substrate/Competitorn/a
Meas. Tech.ChEMBL_981694
IC50 297±n/a nM
Citation Murphy, JMArmijo, ALNomme, JLee, CHSmith, QALi, ZCampbell, DOLiao, HINathanson, DAAustin, WRLee, JTDarvish, RWei, LWang, JSu, YDamoiseaux, RSadeghi, SPhelps, MEHerschman, HRCzernin, JAlexandrova, ANJung, MELavie, ARadu, CG Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem56:6696-708 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxycytidine kinase
Name:Deoxycytidine kinase
Synonyms:dCK
Type:PROTEIN
Mol. Mass.:30510.65
Organism:Homo sapiens
Description:ChEMBL_1437135
Residue:260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50440157
NameBDBM50440157
Synonyms:CHEMBL2426596
TypeSmall organic molecule
Emp. Form.C17H19FN6O2S2
Mol. Mass.422.5
SMILESCOc1ccc(cc1OCCCF)-c1nc(CSc2nc(N)nc(N)n2)cs1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a