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Target
ATP-dependent DNA helicase Q1
Ligand
BDBM50440533
Substrate
n/a
Meas. Tech.
ChEMBL_983200 (CHEMBL2428259)
IC50
>50000±n/a nM
Citation
 Rosenthal, AS; Dexheimer, TS; Gileadi, O; Nguyen, GH; Chu, WK; Hickson, ID; Jadhav, A; Simeonov, A; Maloney, DJ Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorg Med Chem Lett 23:5660-6 (2013) [PubMed]  Article 
Target
Name:
ATP-dependent DNA helicase Q1
Synonyms:
DNA helicase, RecQ-like type 1 | DNA-dependent ATPase Q1 | RECQ1 | RECQ1_HUMAN | RECQL | RECQL1 | RecQ protein-like 1
Type:
PROTEIN
Mol. Mass.:
73468.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103669
Residue:
649
Sequence:
MASVSALTEELDSITSELHAVEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRVLMAQHFDEVWNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTLPREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNSFRAESSQTCHSEQGDKKMEEKNSGNFQKKAANMLQQSGSKNTGAKKRKIDDA
  
Inhibitor
Name:
BDBM50440533
Synonyms:
CHEMBL2426169
Type:
Small organic molecule
Emp. Form.:
C15H9FN6OS
Mol. Mass.:
340.335
SMILES:
Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C#N
Structure:
Search PDB for entries with ligand similarity: