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Target
Isoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)
Ligand
BDBM50440614
Substrate
n/a
Meas. Tech.
ChEMBL_983397 (CHEMBL2429067)
Kd
9400±n/a nM
Citation
 James, LI; Korboukh, VK; Krichevsky, L; Baughman, BM; Herold, JM; Norris, JL; Jin, J; Kireev, DB; Janzen, WP; Arrowsmith, CH; Frye, SV Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem 56:7358-71 (2013) [PubMed]  Article 
Target
Name:
Isoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)
Synonyms:
H-l(3)mbt | H-l(3)mbt protein | KIAA0681 | L(3)mbt protein homolog | L(3)mbt-like | L3MBT | L3MBTL | L3MBTL1 | LMBL1_HUMAN | Lethal(3)malignant brain tumor-like protein 1 | Lethal(3)malignant brain tumor-like protein 1 (4) | Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
Type:
Protein
Mol. Mass.:
83871.06
Organism:
Homo sapiens (Human)
Description:
Q9Y468-4
Residue:
752
Sequence:
MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK
  
Inhibitor
Name:
BDBM50440614
Synonyms:
CHEMBL2426364
Type:
Small organic molecule
Emp. Form.:
C32H43N5O2
Mol. Mass.:
529.7161
SMILES:
O=C(N1CCC(CC1)N1CCCC1)c1ccc(C(=O)N2CCC(CC2)N2CCCC2)c(Nc2ccccc2)c1
Structure:
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