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Target
Probable G-protein coupled receptor 142
Ligand
BDBM50440713
Substrate
n/a
Meas. Tech.
ChEMBL_985961 (CHEMBL2432193)
EC50
37±n/a nM
Citation
 Yu, M; Lizarzaburu, M; Motani, A; Fu, Z; Du, X; Liu, JJ; Jiao, X; Lai, S; Fan, P; Fu, A; Liu, Q; Murakoshi, M; Nara, F; Oda, K; Okuyama, R; Reagan, JD; Watanabe, N; Yamazaki, M; Xiong, Y; Zhang, Y; Zhuang, R; Lin, DC; Houze, JB; Medina, JC; Li, L Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies. ACS Med Chem Lett 4:829-34 (2013) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2
Type:
PROTEIN
Mol. Mass.:
51127.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_985961
Residue:
462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
  
Inhibitor
Name:
BDBM50440713
Synonyms:
CHEMBL2430977
Type:
Small organic molecule
Emp. Form.:
C23H25N7OS
Mol. Mass.:
447.556
SMILES:
CNc1cc(ccn1)-c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cncs2)n(C)n1 |r|
Structure:
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