Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase A chain
Ligand
BDBM50441115
Substrate
n/a
Meas. Tech.
ChEMBL_984205 (CHEMBL2432258)
Kd
5000±n/a nM
Citation
 Fauber, BP; Dragovich, PS; Chen, J; Corson, LB; Ding, CZ; Eigenbrot, C; Giannetti, AM; Hunsaker, T; Labadie, S; Liu, Y; Liu, Y; Malek, S; Peterson, D; Pitts, K; Sideris, S; Ultsch, M; VanderPorten, E; Wang, J; Wei, B; Yen, I; Yue, Q Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett 23:5533-9 (2013) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50441115
Synonyms:
CHEMBL2430713
Type:
Small organic molecule
Emp. Form.:
C19H17ClN4O2
Mol. Mass.:
368.817
SMILES:
C[C@@H](Nc1nc(cnc1N)-c1cccc(c1)C(O)=O)c1ccc(Cl)cc1 |r|
Structure:
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