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TargetLactate dehydrogenase A (LDHA)
LigandBDBM50441138
Substrate/Competitorn/a
Meas. Tech.ChEMBL_984206
IC50 500±n/a nM
Citation Fauber, BPDragovich, PSChen, JCorson, LBDing, CZEigenbrot, CGiannetti, AMHunsaker, TLabadie, SLiu, YLiu, YMalek, SPeterson, DPitts, KSideris, SUltsch, MVanderPorten, EWang, JWei, BYen, IYue, Q Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett23:5533-9 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lactate dehydrogenase A (LDHA)
Name:L-lactate dehydrogenase A chain
Synonyms:Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | Renal carcinoma antigen NY-REN-59
Type:Protein
Mol. Mass.:36694.85
Organism:Homo sapiens (Human)
Description:P00338::PDB Code: 4ajp
Residue:332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50441138
NameBDBM50441138
Synonyms:CHEMBL2430727
TypeSmall organic molecule
Emp. Form.C20H19ClN4O2
Mol. Mass.382.843
SMILESC[C@@H](Nc1nc(cnc1N)-c1cc(ccc1C)C(O)=O)c1ccc(Cl)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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