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Target
Hexokinase-4
Ligand
BDBM50441156
Substrate
n/a
Meas. Tech.
ChEMBL_984799 (CHEMBL2432301)
EC50
77±n/a nM
Citation
 Hinklin, RJ; Boyd, SA; Chicarelli, MJ; Condroski, KR; DeWolf, WE; Lee, PA; Lee, W; Singh, A; Thomas, L; Voegtli, WC; Williams, L; Aicher, TD Identification of a new class of glucokinase activators through structure-based design. J Med Chem 56:7669-78 (2013) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50441156
Synonyms:
CHEMBL2430860
Type:
Small organic molecule
Emp. Form.:
C22H20N4OS2
Mol. Mass.:
420.55
SMILES:
Cc1csc(Nc2ncc(SCc3ccccn3)cc2OCc2ccccc2)n1
Structure:
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