Reaction Details Report a problem with these data
Target
Heme oxygenase 2
Ligand
BDBM50441452
Substrate
n/a
Meas. Tech.
ChEMBL_988011 (CHEMBL2438669)
IC50
1500±n/a nM
Citation
 Vlahakis, JZ; Vukomanovic, D; Nakatsu, K; Szarek, WA Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position. Bioorg Med Chem 21:6788-95 (2013) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM50441452
Synonyms:
CHEMBL2436287
Type:
Small organic molecule
Emp. Form.:
C19H20BrN3
Mol. Mass.:
370.286
SMILES:
Brc1cccc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Structure:
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