Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 2-alpha kinase 1
Ligand
BDBM50442166
Substrate
n/a
Meas. Tech.
ChEMBL_993291 (CHEMBL2443948)
IC50
460±n/a nM
Citation
Axten, JM; Romeril, SP; Shu, A; Ralph, J; Medina, JR; Feng, Y; Li, WH; Grant, SW; Heerding, DA; Minthorn, E; Mencken, T; Gaul, N; Goetz, A; Stanley, T; Hassell, AM; Gampe, RT; Atkins, C; Kumar, R Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett 4:964-8 (2013) [PubMed] Article
More Info.:
Target
Name:
Eukaryotic translation initiation factor 2-alpha kinase 1
Synonyms:
E2AK1_HUMAN | EIF2AK1 | HRI | KIAA1369
Type:
PROTEIN
Mol. Mass.:
71098.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467744
Residue:
630
Sequence:
MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFPFAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGGVG