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Target
Monocarboxylate transporter 4
Ligand
BDBM50442704
Substrate
n/a
Meas. Tech.
ChEMBL_989589 (CHEMBL2444904)
IC50
>30000±n/a nM
Citation
 Draoui, N; Schicke, O; Fernandes, A; Drozak, X; Nahra, F; Dumont, A; Douxfils, J; Hermans, E; Dogné, JM; Corbau, R; Marchand, A; Chaltin, P; Sonveaux, P; Feron, O; Riant, O Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem 21:7107-17 (2013) [PubMed]  Article 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM50442704
Synonyms:
CHEMBL2442506
Type:
Small organic molecule
Emp. Form.:
C18H14O5
Mol. Mass.:
310.3008
SMILES:
Cc1c(C(O)=O)c(=O)oc2cc(OCc3ccccc3)ccc12
Structure:
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