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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM82546
Substrate
n/a
Meas. Tech.
ChEMBL_990373 (CHEMBL2445786)
Ki
44000±n/a nM
Citation
 Bolchi, C; Valoti, E; Binda, M; Fasoli, F; Ferrara, R; Fumagalli, L; Gotti, C; Matucci, R; Vistoli, G; Pallavicini, M Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. Bioorg Med Chem Lett 23:6481-5 (2013) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM82546
Synonyms:
CAS_14721-69-8 | MCC | N-methylcarbamylcholine | NMCC
Type:
Small organic molecule
Emp. Form.:
C7H17N2O2
Mol. Mass.:
161.2215
SMILES:
CNC(=O)OCC[N+](C)(C)C
Structure:
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