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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50443004
Substrate
n/a
Meas. Tech.
ChEMBL_1276823 (CHEMBL3089491)
IC50
4.0±n/a nM
Citation
 Shirude, PS; Madhavapeddi, P; Naik, M; Murugan, K; Shinde, V; Nandishaiah, R; Bhat, J; Kumar, A; Hameed, S; Holdgate, G; Davies, G; McMiken, H; Hegde, N; Ambady, A; Venkatraman, J; Panda, M; Bandodkar, B; Sambandamurthy, VK; Read, JA Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis. J Med Chem 56:8533-42 (2013) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM50443004
Synonyms:
CHEMBL3088173
Type:
Small organic molecule
Emp. Form.:
C18H16F2N6OS2
Mol. Mass.:
434.486
SMILES:
Cc1csc(n1)C(C)(O)c1nnc(Nc2ccn(Cc3c(F)cccc3F)n2)s1
Structure:
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