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TargetBromodomain-containing protein 7
LigandBDBM50443232
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1277428
Ki 2720±n/a nM
Citation Zhang, GPlotnikov, ANRusinova, EShen, TMorohashi, KJoshua, JZeng, LMujtaba, SOhlmeyer, MZhou, MM Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem56:9251-64 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 7
Name:Bromodomain-containing protein 7
Synonyms:75 kDa bromodomain protein | BP75 | BRD7 | CELTIX1 | Protein CELTIX-1
Type:PROTEIN
Mol. Mass.:74135.71
Organism:Homo sapiens (Human)
Description:ChEMBL_107970
Residue:651
Sequence:
MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGHDSSLFEDKNDHDKHKD
RKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAEKDLQCHAPVRLDLPPEKP
LTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFST
MKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSL
KQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGDAEAHAFKSPSKENKKKDKD
MLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPI
VGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFAN
ISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLTKGGHSRTLQEME
MSLPEDEGHTRTLDTAKEMEITEVEPPGRLDSSTQDRLIALKAVTNFGVPVEVFDSEEAE
IFQKKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMHLAEQVTNNLKELAQQV
TPGDIVSTYGVRKAMGISIPSPVMENNFVDLTEDTEEPKKTDVAECGPGGS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50443232
NameBDBM50443232
Synonyms:CHEMBL3086883
TypeSmall organic molecule
Emp. Form.C18H17N5O3S
Mol. Mass.383.424
SMILESCc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)cc1O |w:4.3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a