Reaction Details Report a problem with these data
Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50443351
Substrate
n/a
Meas. Tech.
ChEMBL_1275525 (CHEMBL3090540)
IC50
0.180000±n/a nM
Citation
Debenham, JS; Graham, TH; Verras, A; Zhang, Y; Clements, MJ; Kuethe, JT; Madsen-Duggan, C; Liu, W; Bhatt, UR; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Li, X; Lisnock, J; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xu, S; Hale, JJ; Pinto, S; Shen, DM Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett 23:6228-33 (2013) [PubMed] Article
More Info.:
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH