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Target
Neuropeptide S receptor
Ligand
BDBM50331943
Substrate
n/a
Meas. Tech.
ChEMBL_1276615 (CHEMBL3088900)
IC50
10.0±n/a nM
Citation
 Patnaik, S; Marugan, JJ; Liu, K; Zheng, W; Southall, N; Dehdashti, SJ; Thorsell, A; Heilig, M; Bell, L; Zook, M; Eskay, B; Brimacombe, KR; Austin, CP Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. J Med Chem 56:9045-56 (2013) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14
Type:
PROTEIN
Mol. Mass.:
42692.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1276607
Residue:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50331943
Synonyms:
5-phenyl-2-(2-(piperidine-1-carbonyl)phenyl)-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-one | CHEMBL1290004
Type:
Small organic molecule
Emp. Form.:
C24H23N3O2
Mol. Mass.:
385.4583
SMILES:
O=C(N1CCCCC1)c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O
Structure:
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