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Target
5'-nucleotidase
Ligand
BDBM50443529
Substrate
n/a
Meas. Tech.
ChEMBL_1275400 (CHEMBL3090249)
IC50
41000±n/a nM
Citation
 Iqbal, J; Saeed, A; Raza, R; Matin, A; Hameed, A; Furtmann, N; Lecka, J; Sévigny, J; Bajorath, J Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors. Eur J Med Chem 70:685-91 (2013) [PubMed]  Article 
Target
Name:
5'-nucleotidase
Synonyms:
5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE
Type:
Enzyme
Mol. Mass.:
63371.54
Organism:
Homo sapiens (Human)
Description:
P21589
Residue:
574
Sequence:
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
  
Inhibitor
Name:
BDBM50443529
Synonyms:
CHEMBL3087999
Type:
Small organic molecule
Emp. Form.:
C10H8N2O6S
Mol. Mass.:
284.245
SMILES:
Nc1c(O)cc(c2cc(ccc12)[N+]([O-])=O)S(O)(=O)=O
Structure:
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