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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50443629
Substrate
n/a
Meas. Tech.
ChEMBL_1279843 (CHEMBL3095702)
IC50
2.0±n/a nM
Citation
 Blass, B N-[4-(1H-Pyrazolo[3,4-B]pyrazin-6yl)-phenyl]-sulonamides and Their Use As Pharmaceuticals. ACS Med Chem Lett 4:1022-4 (2013) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50443629
Synonyms:
CHEMBL3092467 | US9174993, 16 | US9221828, 16
Type:
Small organic molecule
Emp. Form.:
C19H16ClN5O3S
Mol. Mass.:
429.88
SMILES:
COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1cnc2c(C)n[nH]c2n1
Structure:
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