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Target
Cytochrome P450 2D6
Ligand
BDBM50443781
Substrate
n/a
Meas. Tech.
ChEMBL_1280376 (CHEMBL3095536)
IC50
600±n/a nM
Citation
 Wilson, DM; Apps, J; Bailey, N; Bamford, MJ; Beresford, IJ; Briggs, MA; Calver, AR; Crook, B; Davis, RP; Davis, S; Dean, DK; Harris, L; Heightman, TD; Panchal, T; Parr, CA; Quashie, N; Steadman, JG; Schogger, J; Sehmi, SS; Stean, TO; Takle, AK; Trail, BK; White, T; Witherington, J; Worby, A; Medhurst, AD The discovery of the benzazepine class of histamine H3 receptor antagonists. Bioorg Med Chem Lett 23:6897-901 (2013) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50443781
Synonyms:
CHEMBL3094120
Type:
Small organic molecule
Emp. Form.:
C22H27NO
Mol. Mass.:
321.4559
SMILES:
C(Oc1ccc2CCN(CCc2c1)C1CCCC1)c1ccccc1
Structure:
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