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TargetNicotinamide phosphoribosyltransferase
LigandBDBM50443800
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1280599
IC50 0.300000±n/a nM
Citation Christensen, MKErichsen, KDOlesen, UHTjørnelund, JFristrup, PThougaard, ANielsen, SJSehested, MJensen, PBLoza, EKalvinsh, IGarten, AKiess, WBjörkling, F Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship. J Med Chem56:9071-88 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM50443800
NameBDBM50443800
Synonyms:CHEMBL3094255
TypeSmall organic molecule
Emp. Form.C25H41N7O4S
Mol. Mass.535.703
SMILESO=S(=O)(CCCCCCNC(NC#N)=Nc1ccncc1)N(OCCN1CCOCC1)C1CCCCC1 |w:14.14|
Structure
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n/a