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Target
Cyclin-dependent kinase 2
Ligand
BDBM50444932
Substrate
n/a
Meas. Tech.
ChEMBL_1281339 (CHEMBL3101312)
Kd
76±n/a nM
Citation
 Deng, Y; Shipps, GW; Zhao, L; Siddiqui, MA; Popovici-Muller, J; Curran, PJ; Duca, JS; Hruza, AW; Fischmann, TO; Madison, VS; Zhang, R; McNemar, CW; Mayhood, TW; Syto, R; Annis, A; Kirschmeier, P; Lees, EM; Parry, DA; Windsor, WT Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Bioorg Med Chem Lett 24:199-203 (2013) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50444932
Synonyms:
CHEMBL3099764
Type:
Small organic molecule
Emp. Form.:
C27H30N2O6
Mol. Mass.:
478.5369
SMILES:
CCCCCCc1ccc2nc(cc(C(O)=O)c2c1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC |r|
Structure:
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