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Target
Calmodulin-domain protein kinase 1
Ligand
BDBM50446167
Substrate
n/a
Meas. Tech.
ChEMBL_1287980 (CHEMBL3110679)
IC50
11±n/a nM
Citation
 Zhang, Z; Ojo, KK; Vidadala, R; Huang, W; Geiger, JA; Scheele, S; Choi, R; Reid, MC; Keyloun, KR; Rivas, K; Siddaramaiah, LK; Comess, KM; Robinson, KP; Merta, PJ; Kifle, L; Hol, WG; Parsons, M; Merritt, EA; Maly, DJ; Verlinde, CL; Van Voorhis, WC; Fan, E Potent and selective inhibitors of CDPK1 from ACS Med Chem Lett 5:40-44 (2014) [PubMed]  Article 
Target
Name:
Calmodulin-domain protein kinase 1
Synonyms:
Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57248.42
Organism:
Toxoplasma gondii
Description:
n/a
Residue:
507
Sequence:
MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN
  
Inhibitor
Name:
BDBM50446167
Synonyms:
CHEMBL3108916 | US9518026, Example 8 | US9956214, Compound 8
Type:
Small organic molecule
Emp. Form.:
C23H29N5O2
Mol. Mass.:
407.5087
SMILES:
CCOc1ccc2cc(ccc2c1)-c1nn(CC2CCN(C)CC2)c(N)c1C(N)=O
Structure:
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