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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50446283
Substrate
n/a
Meas. Tech.
ChEMBL_1288032 (CHEMBL3110731)
IC50
9.0±n/a nM
Citation
 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y Discovery of Tertiary Amine and Indole Derivatives as Potent ROR?t Inverse Agonists. ACS Med Chem Lett 5:65-8 (2014) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor
Type:
PROTEIN
Mol. Mass.:
58133.31
Organism:
Mus musculus
Description:
ChEMBL_103664
Residue:
516
Sequence:
MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
  
Inhibitor
Name:
BDBM50446283
Synonyms:
CHEMBL3109235
Type:
Small organic molecule
Emp. Form.:
C26H24Cl2N2O3S
Mol. Mass.:
515.451
SMILES:
CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(Cl)cc4Cl)ccc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: