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Target
Platelet-derived growth factor receptor beta
Ligand
BDBM50446314
Substrate
n/a
Meas. Tech.
ChEMBL_1286760 (CHEMBL3111865)
IC50
28±n/a nM
Citation
 Hicken, EJ; Marmsater, FP; Munson, MC; Schlachter, ST; Robinson, JE; Allen, S; Burgess, LE; DeLisle, RK; Rizzi, JP; Topalov, GT; Zhao, Q; Hicks, JM; Kallan, NC; Tarlton, E; Allen, A; Callejo, M; Cox, A; Rana, S; Klopfenstein, N; Woessner, R; Lyssikatos, JP Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability. ACS Med Chem Lett 5:78-83 (2014) [PubMed]  Article 
Target
Name:
Platelet-derived growth factor receptor beta
Synonyms:
2.7.10.1 | Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF-R-beta | PDGFR-1 | PDGFR-beta | PGFRB_MOUSE | Pdgfr | Pdgfr1 | Pdgfrb | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor | Platelet-derived growth factor receptor 1
Type:
Enzyme
Mol. Mass.:
122771.00
Organism:
Mus musculus (mouse)
Description:
P05622
Residue:
1098
Sequence:
MGLPGVIPALVLRGQLLLSVLWLLGPQTSRGLVITPPGPEFVLNISSTFVLTCSGSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPELSERKRIYIFVPDPTMGFLPMDSEDLFIFVTDVTETTIPCRVTDPQLEVTLHEKKVDIPLHVPYDHQRGFTGTFEDKTYICKTTIGDREVDSDTYYVYSLQVSSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINISVIENGYVRLLETLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHEDDEVQLSFKLQVNVPVRVLELSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGGDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHSLRSPLDTSSVLYTAVQPNESDNDYIIPLPDPKPDVADEGLPEGSPSLASSTLNEVNTSSTISCDSPLELQEEPQQAEPEAQLEQPQDSGCPGPLAEAEDSFL
  
Inhibitor
Name:
BDBM50446314
Synonyms:
CHEMBL3109348
Type:
Small organic molecule
Emp. Form.:
C25H28N4O3
Mol. Mass.:
432.5148
SMILES:
COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CC[C@H](N)CC3)c2n1 |r,wU:26.28,wD:23.24,(30.19,-22.56,;31.74,-22.58,;32.49,-23.91,;34.04,-23.93,;34.79,-25.28,;36.34,-25.29,;37.28,-26.52,;38.79,-26.32,;39.38,-24.91,;40.83,-24.4,;40.8,-22.86,;39.33,-22.41,;38.46,-23.68,;36.93,-23.88,;42.17,-25.17,;42.17,-26.71,;43.51,-27.49,;44.84,-26.71,;46.18,-27.48,;47.52,-26.7,;47.51,-25.15,;46.17,-24.39,;46.16,-22.84,;47.48,-22.08,;48.8,-22.86,;50.13,-22.1,;50.15,-20.57,;51.48,-19.81,;48.82,-19.79,;47.48,-20.55,;44.84,-25.16,;43.5,-24.4,)|
Structure:
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