Reaction Details Report a problem with these data
Target
Aurora kinase A
Ligand
BDBM50446440
Substrate
n/a
Meas. Tech.
ChEMBL_1287772 (CHEMBL3111604)
IC50
>100000±n/a nM
Citation
 Naud, S; Westwood, IM; Faisal, A; Sheldrake, P; Bavetsias, V; Atrash, B; Cheung, KM; Liu, M; Hayes, A; Schmitt, J; Wood, A; Choi, V; Boxall, K; Mak, G; Gurden, M; Valenti, M; de Haven Brandon, A; Henley, A; Baker, R; McAndrew, C; Matijssen, B; Burke, R; Hoelder, S; Eccles, SA; Raynaud, FI; Linardopoulos, S; van Montfort, RL; Blagg, J Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem 56:10045-65 (2013) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50446440
Synonyms:
CHEMBL3109943
Type:
Small organic molecule
Emp. Form.:
C26H26ClN7O2
Mol. Mass.:
503.983
SMILES:
Cn1ccc(n1)-c1ccc(Nc2cc3n(C(=O)OC(C)(C)C)c(cc3cn2)-c2cnn(C)c2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: