Reaction Details Report a problem with these data
Target
3-hydroxyanthranilate 3,4-dioxygenase
Ligand
BDBM50446510
Substrate
n/a
Meas. Tech.
ChEMBL_1287918 (CHEMBL3112337)
IC50
2800±n/a nM
Citation
Vallerini, GP; Amori, L; Beato, C; Tararina, M; Wang, XD; Schwarcz, R; Costantino, G 2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents. J Med Chem 56:9482-95 (2014) [PubMed] Article
More Info.:
Target
Name:
3-hydroxyanthranilate 3,4-dioxygenase
Synonyms:
3-HAO | 3-hydroxyanthranilate oxygenase | 3-hydroxyanthranilic acid dioxygenase | 3HAO_RAT | HAD | Haao
Type:
PROTEIN
Mol. Mass.:
32577.72
Organism:
Rattus norvegicus
Description:
ChEMBL_108018
Residue:
286
Sequence:
MERCVRVKSWVEENRASFQPPVCNKLMHREQLKIMFVGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGEHRDVVIRQGEIFLLPARVPHSPQRFANTMGLVIERRRMETELDGLRYYVGDTEDVLFEKWFHCKDLGTQLAPIIQEFFHSEQYRTGKPNPDQLLKEPPFPLSTRSVMEPMSLKAWLESHSRELQAGTSLSLFGDSYETQVIAHGQGSSKGPRQDVDVWLWQLEGSSKVTMGGQCVALAPDDSLLVPAGFSYMWERAQGSVALSVTQDPACKKPLG