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Target
Polyunsaturated fatty acid lipoxygenase ALOX12
Ligand
BDBM50447175
Substrate
n/a
Meas. Tech.
ChEMBL_1290357 (CHEMBL3118870)
IC50
1000±n/a nM
Citation
 Luci, DK; Jameson, JB; Yasgar, A; Diaz, G; Joshi, N; Kantz, A; Markham, K; Perry, S; Kuhn, N; Yeung, J; Kerns, EH; Schultz, L; Holinstat, M; Nadler, JL; Taylor-Fishwick, DA; Jadhav, A; Simeonov, A; Holman, TR; Maloney, DJ Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem 57:495-506 (2014) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX12
Synonyms:
Alox12 | Alox12p | Arachidonate 12-lipoxygenase | LOX12_MOUSE
Type:
PROTEIN
Mol. Mass.:
75384.34
Organism:
Mus musculus
Description:
ChEMBL_1290357
Residue:
663
Sequence:
MGRYRVRVVTGAWLFSGSLNLVRLWLVGEHREAKLELQLRPARGKEEEFDFDVPEDLGPLQFVKLHKQHTVVDDAWFCNLITVQGPGTSAEAVFPCYRWVQGEGILSLPEGTARLAGDNALDVFQKYREKELKERQQTYCWATWKEGLPQTIAADCKDDLPPNMRFHEEKRLDFEWTLKAGVLEMGLKRVYTLLRSWNHLEDFDQIFWGQKSALAEKVHQCWQEDELFGYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELKNGSLFEADFILLDGIPANVIRGEPQYLAAPLVMLRMDPGGKLLPMAIQIQPPNPSSPAPTLFLPSDPPLAWLLAKIWVRNSDFQLQELQFHLLNTHLVAEVIAVATMRCLPGLHPIFKLLVPHIRYTMEINTRSRTQLISDGGIFDQVVSTGGGGHVQLLTRAVAQLTYHSLCPPDDLANRGLLRIPSALYARDALQLWEVTARYVKGMVHLFYQSDDIVRGDPELQAWCREITEVGLCHAQDRGFPVSFQSRAQLCHFLTMCVFTCTAQHAAINQGQLDWYGWVPNAPCTMRMPPPTSKDDVTMETVMGSLPDVQKACLQMTITWHLGRLQPDMVPLGHHTEKYFSDPRTKAVLSQFQADLDNLEKEITARNEQLDLPYEYLKPSRIENSITI
  
Inhibitor
Name:
BDBM50447175
Synonyms:
CHEMBL3113165 | US10752581, Compound 35
Type:
Small organic molecule
Emp. Form.:
C21H19N3O4S2
Mol. Mass.:
441.523
SMILES:
COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nc3ccccc3s2)c1O
Structure:
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